Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

Search Within Results

7,456 – 7,470 of 60,533 results

7,456

Cayman Chemical ANTIBODY SpInorphIn 500ug

A peptide inhibitor of enkephalin-degrading enzymes; inhibits aminopeptidase, dipeptidyl aminopeptidase, ACE, and enkephalinase (IC50s = 3.3, 1.4, 2.4, and 10 UG/ml, respectively, for the monkey brain enzymes); selective for these enzymes over human serum aminopeptidase A (IC50 = >100 UG/ml), as well as porcine kidney aminopeptidase B, aminopeptidase M, and DPP-1, -2, -3, and -4 (IC50s = >55 UG/ml for all); inhibits chemotaxis, production of ROS, and exocytosis of glucuronidase and collagenase in PMNs; potentiates enkephalin-induced action potentials in rat hippocampal slices; enhances the antinociceptive effects of Leu-enkephalin in mice at 5 UG/animal

Pricing & Availability

7,457

Cayman Chemical CVT-6883, Purity: ≥98%, CAS: 752222-83-6, 1 mg

An adenosine A2B receptor antagonist (Ki = 22 nM); selective for adenosine A2B over adenosine A1, A2A, and A3 receptors (Kis = 1,940, 3,280, and 1,070 nM, respectively), as well as a panel of 84 proteins at 10 µM; decreases allergen challenge-induced BALF eosinophil and lymphocyte infiltration and airway reactivity in a mouse model of allergic asthma at 6 mg/kg; decreases fibrosis in the non-infarct zone, improves ejection fractions, and reduces ventricular tachycardia in a rat model of myocardial infarction

Pricing & Availability

7,458

Medchemexpress LLC GPNMB/Osteoactivin 5ug

Recombinant human GPNMB (Osteoactivin), expressed in HEK293 cells with a C-terminal His tag, is supplied as a lyophilized, glycosylated protein of >95% purity and is functionally active in cell-based assays. It is intended for in vitro receptor binding, signaling studies, and assay development; aliquot and store frozen after reconstitution to preserve activity.

High purity glycosylated protein suitable for functional assays.
Expressed in mammalian cells for native post-translational modifications.
Lyophilized format for long-term storage and transport.
Validated activity in cell proliferation assays.
Stable when aliquoted and stored at -20°C or -80°C for extended storage.

Pricing & Availability

7,459

Cayman Chemical YVAD-CHO (trifluoroacetate salt), Purity: ≥95%, 5 mg

A caspase-1/ICE inhibitor; prevents ICE-like and CPP32-like proteinase activity and inhibits apoptosis induced by ceramide or irinotecan in 4B1 cells at 600 µM; prevents chromogranin A-induced cell death of primary rat microglia at 100 µM

Pricing & Availability

7,460

Cayman Chemical Tauro-Obeticholic Acid (sodium salt), Purity: ≥98%, CAS: 2278141-79-8, 5 mg

An active metabolite of obeticholic acid

Pricing & Availability

7,461

Medchemexpress LLC Oncrasin-72 | 92407-90-4 | 97.6% | 271.74 | C16H14ClNO | 5 MG

Oncrasin-72 is a synthetic small-molecule research compound reported to inhibit RNA polymerase II and to induce cell death in susceptible human cancer cell lines. It is offered in milligram-scale quantities for laboratory use and is characterized by its published chemical identifiers and analytical purity.

Provides well-characterized small-molecule activity for mechanistic studies.
High chemical purity suitable for in vitro research applications.
Available in multiple milligram pack sizes for flexible dosing.
Appropriate for cellular assays and transcriptional regulation studies.
Documented chemical identifiers simplify database referencing.

Pricing & Availability

7,462

Cayman Chemical 3,5,6,7,8,3',4'-Heptamethoxyflavone, Purity: ≥98%, CAS: 1178-24-1, 5 mg

A polymethoxyflavone; inhibits the efflux of Hoechst 33342 by BCRP and rhodamine 123 by P-gp in MDCK cells expressing the human transporters (IC50s = 1.4 and 31 µM, respectively); prevents UVB-induced decreases in type I procollagen in HDFn cells at 50, 100, and 200 µg/ml; inhibits the proliferation of B16 melanoma 4A5, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cells (IC50s = 38, 29, and 9 µM, respectively); prevents corticosterone-induced increases in immobility time in the forced swim test in mice at 50 mg/kg

Pricing & Availability

7,463

Medchemexpress LLC 3'-((3-hydroxy-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)-biphenyl-4-carboxamide | 824983-94-0 | 99.9% | 25 MG

FEN1-IN-2 is a small-molecule inhibitor of flap endonuclease 1 (FEN1) used for biochemical and cellular research. It potently inhibits FEN1 (IC50 3 nM) and shows activity against XPG (IC50 226 nM).

Potent FEN1 inhibitor with an IC50 of 3 nM.
Shows measurable activity against XPG (IC50 226 nM).
High purity suitable for research use (99.94%).
Molecular weight 393.42 g/mol, formula C20H15N3O4S.
Available in 25 MG quantities for laboratory experiments.

Pricing & Availability

7,464

Cayman Chemical M2I-1, Purity: ≥98%, CAS: 312271-03-7, 5 mg

An inhibitor of the Mad2-Cdc20 interaction; inhibits Mad2 binding to Cdc20111-138 from 6.25-100 μM; reduces paclitaxel-induced increases in mitotic duration in HeLa cells at 25 μM; reduces 4-cell embryo and blastocyst formation in hydrogen peroxide-exposed mouse zygotes from 20-120 μM, as well as increases the rate of sex chromosome mosaicism in male mouse in vitro fertilization-derived embryos

Pricing & Availability

7,465

Cayman Chemical CHM-1, Purity: ≥98%, CAS: 154554-41-3, 1 mg

An inhibitor of tubulin polymerization (IC50 = 0.68 µM); inhibits chochicine tubulin binding at 5 µM; inhibits the growth of K562, NCI H226, HCT116, OVCAR-3, RXF 393L, SK-MEL-5, SF-268, and SF-295 cancer cells (mean GI50 = 130 nM); induces apoptosis in HA22T hepatocellular carcinoma cells; reduces tumor volume and increases survival in an HA22T mouse xenograft model at 10 mg/kg

Pricing & Availability

7,466

Cayman Chemical Lidocaine-d10, Purity: ≥99% deuterated forms (d1-d10), CAS: 851528-09-1, 5 mg

An internal standard for the quantification of lidocaine by GC- or LC-MS

Pricing & Availability

7,467

Cayman Chemical Lotusine, Purity: ≥98%, CAS: 6871-67-6, 5 mg

An alkaloid with diverse biological activities; increases cAMP levels in rat myocardium at 0.1-3 µM and cGMP levels in rabbit corpus cavernosum in a concentration-dependent manner; prevents doxorubicin-induced lipid peroxidation in H9c2 embryonic rat cardiomyocytes; increases LVP, LVEDP, and SAP in anesthetized rats at 5 mg/kg

Pricing & Availability

7,468

Cayman Chemical BB-22 7-hydroxyisoquinoline isomer, Purity: ≥98%, CAS: 2365471-55-0, 5 mg

BB-22 7-hydroxyisoquinoline isomer differs from BB-22 structurally by having the quinoline group replaced with an isoquinoline group attached at its seven position; intended for forensic and research applications

Pricing & Availability

7,469

Cayman Chemical PRT060318, Purity: ≥98%, CAS: 1194961-19-7, 5 mg

A potent and selective Syk inhibitor (IC50 = 4 nM); inhibits 92% of Syk activity, while other kinases retain >70% activity, at a concentration of 50 nM in a panel of 270 kinases; inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 = 2.5 μM); prevents thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia; induces CLL B cell apoptosis and inhibits the secretion of chemokines CCL3, CCL4, and CXCL13; inhibits CLL B cell chemotaxis and pseudoemperipolesis

Pricing & Availability

7,470

Cayman Chemical Folitixorin, Purity: ≥75% (mixture of diastereomers), CAS: 3432-99-3, 5 mg

A reduced form of folate and cofactor for thymidylate synthetase; forms a ternary complex with thymidylate synthetase and FdUMP that inhibits thymidylate synthetase activity and DNA synthesis; has synergistic or additive cytotoxic effects against LS 174 or HT-29 human colon cancer cells, respectively, when used in combination with 5-fluorouracil; increases survival and reduces tumor growth in an HT-29 mouse xenograft model at 0.6 mg/animal when administered in combination with 5-fluorouracil

Pricing & Availability

Bioactive Small Molecules

Filtered Search Results

Narrow Results

Medchemexpress LLC GPNMB/Osteoactivin 5ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Oncrasin-72 | 92407-90-4 | 97.6% | 271.74 | C16H14ClNO | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3'-((3-hydroxy-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)-biphenyl-4-carboxamide | 824983-94-0 | 99.9% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GPNMB/Osteoactivin 5ug

Medchemexpress LLC Oncrasin-72 | 92407-90-4 | 97.6% | 271.74 | C16H14ClNO | 5 MG

Medchemexpress LLC 3'-((3-hydroxy-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)-biphenyl-4-carboxamide | 824983-94-0 | 99.9% | 25 MG