Bioactive Small Molecules
Selleck Chemical LLC R-Phycoerythrin E2856-5MG
R-Phycoerythrin(R-PE) phycobiliproteins are isolated from Heterosiphonia japonica R-Phycoerythrin is a novel strong fluorescent probe contains four chromophore-carrying subunits which exhibits extremely bright red-orange fluorescence
Selleck Chemical LLC Buddleja Officinalis Extract E3482-5MG
Buddleja Officinalis Extract is drawed from Buddleja officinalis flower which is reportedly effective in treating inflammation conjunctival hypertension and headache in traditional oriental herbal medicine
Cayman Chemical ANTIBODY 4E2RCat 5mg
An inhibitor of the eIF4E-eIF4G protein-protein interaction (IC50 = 13.5 µM); reduces mRNA translation without inducing apoptosis in L-132 cells at 12.5 µM; decreases intracellular and extracellular SARS-COV titers and the percentage of cells expressing spike glycoprotein in SARS-COV-infected L-132 cells at 6 µM
Medchemexpress LLC CD5L Mouse HEK293 5ug
The CD5L protein is primarily expressed by macrophages and regulates inflammatory responses in infection or atherosclerosis CD5L is incorporated into adipocytes via CD36-mediated endocytosis thereby inhibiting lipid droplet size and affecting lipolysis CD5L Protein Mouse (HEK293 His) is the recombinant mouse-derived CD5L protein expressed by HEK293 with C-6 His labeled tag
Cayman Chemical ANTIBODY FIN56 25mg
An inducer of ferroptosis; induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein; binds to and activates squalene synthase in a GPX4 degradation-independent manner
Cayman Chemical ANTIBODY SenxIn B 1mg
An inhibitor of Cdk8 and Cdk19; inhibits Cdk8 (IC50s = 24-50 nM, depending on assay); selectively inhibits Cdk19 and Cdk8 by 98.6 and 97.8%, respectively, in a panel of >450 kinases at 2 μM but does inhibit MAP4K2 and YSK4 by 69 and 59%, respectively; inhibits cell growth in MCF-7, BT474, and T47D-ER/Luc breast cancer cells in estrogen-containing media at 1.25-5 μM; reduces tumor growth in an MCF-7 mouse xenograft model at 100 mg/kg twice per day; inhibits RANKL-induced differentiation of murine BMDMs into osteoclasts at 1 and 1.5 μM; increases the bone volume fraction and bone mineral density in injured tibiae in a rat model of cancellous bone injury and regeneration when administered locally at 1 μg
Medchemexpress LLC L-2-Aminobutyric acid | 1492-24-6 | 99.4% | 103.12 | 1 G
L-2-Aminobutyric acid (H-Abu-OH) is a non-proteinogenic amino acid found in human tissues and body fluids. It is formed by the transamination of oxobutyric acid. This compound can be used as a precursor for anticonvulsant and anti-tuberculosis agents and is a crucial intermediate in the chemical and pharmaceutical industries. It is elevated in the plasma of children with various conditions.
- Found in human tissues and body fluids
- Precursor for anticonvulsant and anti-tuberculosis agents
- Crucial intermediate in chemical and pharmaceutical industries
- Elevated in plasma in certain medical conditions
Cayman Chemical ANTIBODY LY404187 25mg
A benzothiadiazide positive allosteric modulator of AMPA receptors; increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 µM, respectively, in a calcium influx assay; selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 µM; increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 µM, respectively), but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons; prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease at 0.5 mg/kg per day
Medchemexpress LLC PUMA BH3 | 98.2% | 2384.63 | 10 MG
PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide. It functions as a direct activator of Bak with a Kd of 26 nM. The peptide binds Bak in the canonical BH3-binding groove, leading to its activation.
- P53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide
- Direct activator of Bak
- Kd of 26 nM against Bak
- Binds Bak in the canonical BH3-binding groove
Cayman Chemical ANTIBODY GSK1292263 10mg
A GPR119 agonist (EC50 = 43.9 nM in CHO-K1 cells expressing human GPR119); inhibits T0901317-induced increases in SREBP-1 levels and increases activation of AMPK in HepG2 cells in a concentration-dependent manner; inhibits BCRP and OATP1B1 by 52 and 40%, respectively, at 3 μM
Selleck Chemical LLC UNC2025 S9662-100MG
UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0 35 nM and 0 46 nM respectively UNC2025 also inhibits AXL TRKA TRKC QIK TYRO3 SLK NuaK1 Kit (c-Kit) and Met (c-Met) with IC50 of 1 65 nM 1 67 nM 4 38 nM 5 75 nM 5 83 nM 6 14 nM 7 97 nM 8 18 nM and 364 nM respectively
Apexbio Technology LLC Raclopride 84225-95-6 50mg
Raclopride is a small-molecule antagonist targeting dopamine D2 and D3 receptors It is designed to competitively bind these receptors thereby inhibiting dopaminergic neurotransmission and influencing downstream signaling pathways Raclopride exerts its biological activity primarily through competitive antagonism of the dopamine D2 (Ki 1 8 nM) and D3 receptors (Ki 3 5 nM) Based on these pharmacological properties Raclopride holds research potential in neuroscientific studies investigating dopamine-related neurological conditions such as the underlying molecular mechanisms of schizophrenia and associated psychiatric disorders and in exploring receptor-specific functions in dopaminergic signaling
Cayman Chemical PF-05190457 10mg
An inverse agonist of GHS-R; selectively binds to GHS-R (Ki = 4.37 nM) over M2 mAChRs (Ki = 1,950 nM) and 5-HT2B receptors (IC50 = 3,700 nM); increases glucose-induced insulin secretion in primary human pancreatic islets at 1 µM; potentiates GLP-1-induced intracellular calcium levels in isolated dispersed rat islets at 100 nM; increases ex vivo vagal nerve firing rate in rats when administered intragastrically (EC50 = 10.7 nM)
Medchemexpress LLC CS-VIP 8 hydrochloride | 961.40 | 10 MG
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (Ki = 0.008 μM). It induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity, and regulating HOX gene expression.
- Promising for research of hematological diseases such as leukemia